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A longitudinal cohort study on the effects of reducing farm-level antimicrobial use on Escherichia coli antimicrobial resistance on dairy farms in Québec, Canada

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de Lagarde et al. (2025, article in press) performed an observational cohort study of antimicrobial use (AMU) in Quebec dairy farms. "In conclusion, regulation and possibly other concomitant factors had a positive influence on the judicious use of critical antimicrobials and AMR. Moreover, a farm's AMR profile was better explained by its current than by its historical AMU management."